Troubleshooting Dose-Response Meta-Analysis in R with dosresmeta Package

Troubleshooting Dose-Response Meta-Analysis in R with dosresmeta Package

Hey fellow R users, have you ever struggled with performing a dose-response meta-analysis (DRMA) using the dosresmeta package? I recently came across a Reddit post from someone who’s facing a two-part error while trying to run the analysis. If you’re experiencing similar issues, this post might be helpful.

The error messages aren’t exactly user-friendly, so let’s break them down. The first error occurs when the event data isn’t included, and it’s complaining about missing arguments for cases, n, and type. After adding these, another error pops up, saying that ‘x’ must have a positive length. This usually means that the data frame is empty after filtering.

To troubleshoot this, let’s take a closer look at the code used for data preparation and the dosresmeta function call. It’s essential to ensure that the data is correctly formatted and that the arguments are specified correctly. I’ll walk you through the code and highlight potential issues.

First, the data is loaded and prepared by selecting the required columns, converting the dose variable to numeric, and calculating the log hazard ratio and its standard error. The data is then filtered to remove rows with missing or infinite confidence intervals.

The dosresmeta function is called with the formula logHR ~ dose, specifying the study ID, data, cases, n, type, and covariance. This is where the errors occur.

To fix the issues, we need to ensure that the data is correctly formatted and that the arguments are specified correctly. Double-check that the cases, n, and type arguments are correctly defined and that the data frame isn’t empty after filtering.

If you’re still struggling with the dosresmeta package, feel free to share your code and error messages, and I’ll do my best to help you troubleshoot the issue.

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